Wednesday, April 10, 2013

The Algarve: Not just for golf-mad pensioners | CNN Travel

The southernmost region of Portugal, the Algarve has a reputation for being a retirement home for wealthy British pensioners.

While this is partly the case, the Algarve has moved into the 21st century with a more varied outlook on tourism.

Thanks to golf-mad Brit retirees, the region has become a serious golfing destination, winning awards as Europe's best place to swing a club.

But this delightful area with southern and western Atlantic coasts, and more than 300 warm to hot sunny days each year, has more to offer than the most maddening game ever invented.

The region

Fal?sia Beach, one of hundreds in the Algarve, unspoiled and often empty. The Algarve is a haven for sailors, with seven marinas along its southern Atlantic coast; a world class surfing destination; and a great place for swimming, deep sea fishing, body-boarding, diving and kite-surfing.

On land there's motor racing, tennis, athletics and skydiving. Many of Europe's top soccer teams stay in the Algarve for pre-season training.

When I stayed at the Hotel Quinta do Lago, the Libyan national soccer team was there preparing for a friendly match. OK, they're not Barcelona or Manchester United, but the Libyan team proves the area's worth on the national football circuit.

There are more than 100 beaches along the 200-kilometer coastline and a plethora of luxury spas.

Local heritage reflects the various peoples who have inhabited the Algarve -- Arabs, Romans, Greeks, Phoenicians, Carthaginians and Celts.

The Algarve also has a reputation for some of the best seafood in the world, reflected in the excellent restaurants in the region, which has the highest number of Michelin stars in Portugal.

It's also a place for environmental tourism, centred around the Ria Formosa Nature Reserve, with its 60 kilometers (37 miles) of islands and channels creating a birdwatchers' paradise.

For a completely back to nature eco-tourist vacation, you can get away from modern civilization and backpack along the Via Algarviana.

The 300-kilometer (186 miles) footpath begins in Alcoutim near the Spanish border and ends at Cabo de S?o Vicente, where the southern and western Algarve coasts meet. The path travels through towns that still live according to the traditions of the rural world.

You can pitch your tent wherever you want or stay in local tavernas.

There's plenty of nightlife, especially in Vilamoura, the largest resort town in Europe, and Faro, the region's capital.

Food

Terrace at the Sea Breeze restaurant at the Hotel Quinta do Lago. In the Algarve seafood is king.

Caught daily in the Atlantic, crab, clams, king prawns, sea bass, sea bream, cod and other ocean delicacies are guaranteed to be superb.

Reflecting the region's Moorish heritage (five centuries of Islamic occupation),?Moroccan restaurants serve chicken couscous and traditional lamb tajine.

There are restaurants for every budget, from fast food to Japanese and, of course, Mediterranean.

As Dunas, Martinhal Resort: At the excellent As Dunas restaurant at the Martinhal Resort in Sagre, two people can have a lovely dinner including wine for less than ?40 (US$52).

Seafood, fresh fish and traditional Algarvean dishes adorn the menu; set among the sand dunes of Martinhal beach,?the location is superb.

Martinhal Beach Resort and Hotel, Quinta do Martinhal, Sagres; +351 282 240 200; www.martinhal.com

La Bella Vita: This Italian restaurant does the usual pizza/pasta along with more elbarorate dishes, like scallops with king prawns and rice. Ravioli and dishes featuring truffles are also a speciality.

Algarve Club Atl?ntico, 20 Alfanzina, Carvoeiro; +351 282 358 556; http://bella-vita.pt

O Costa: With panoramic views across the Ria Formosa lagoon and close to the Algarvean capital Faro, O Costa serves a mix of traditional Portuguese, Spanish and other Mediterranean recipes.

A great selection of tapas is available.

Avenida Nascente, Praia da Faro, Faro; +351 289 817 442; www.restauranteocosta.com

Activities

The fourth green at Onyria Palmares. These looks won't kill, but they might frustrate. Golf: The Algarve has a justified reputation as mainland Europe's finest golf destination.

From Onyria Palmares in the west through the five superb courses at Vilamoura, San Lorenzo and the Laranjal course at Quinta do Lago, to Monte Rei in the east (where you can see Spain from the fairways), there are more than 30 championship courses in the region.

For details go to www.algarvegolf.net.

Surfing/kite-surfing: Nowhere else in Europe offers year-round great surfing waves in the morning and steady kite-surfing winds in the afternoon like the southwest tip of the Algarve, between Cabo de Sao Vincente and Sagres.

For details on all watersports available in the Algarve go to www.algarve-watersport.com.

Sailing: With the Portuguese history of seafaring and seven marinas along its southern Atlantic coast it's no surprise that the Algarve has sailing in its blood.

Bring your yacht, hire one or just take a pleasure boat cruise along the 200 kilometer coastline.

Land and water sports: Other water sports include kayaking, deep sea fishing, swimming, snorkeling and scuba diving.

Land sports include ample tennis courts, motor racing at more than 300 kph (185 mph) on the Algarve racetrak, skydiving or soccer at a variety of sports complexes, horseback riding at the Vilamoura equestrian center, mountain biking or trekking through the Algarve mountains and ordinary road cycling.

Culture: Various peoples have inhabited the Algarve -- Arabs (five centuries of Islamic occupation), Romans, Greeks, Phoenicians, Carthaginians and Celts.

The Algarve is home to 13th-century castles, 16th-century churches, modern museums, local arts and crafts, markets and music, from old folk through new wave.

Nature: From stunning Cabo de Sao Vicente, where the west and south Algarve coasts meet, to the Reserva Natural do Sapal de Castro Marim in the east on the Spanish border (and home to one of the largest flamingo habitats in Europe), the Algarve is awash with nature reserves.

The most beautiful is the Parque Natural de Ria Formosa around the region's capital Faro. You can leave civilization behind and rucksack along the 300-kilometer (186 mile) Via Algarviana, a great way to take in the Algarve's natural beauty.

Spa: Here SPA means Sanus Per Algarve ("Health through Algarve") and spa lovers can indulge in aromatherapy, thalassotherapy, sports and therapeutic massages, hot stone therapies, reflexology, yoga or reiki.

You can also visit Caldas de Monchique, a natural spa since Roman times when it was known as Aguas Sagradas (Sacred Waters).

Beach: The Algarve has more than 100 beaches along its 200-kilometer (124 miles) coastline, many of them usually deserted.

Hotels and resorts

The Algarve is home to numerous luxury resorts, many more affordable than you might think. The Algarve is filled with five-star hotels and resorts, plus options for those on a tight budget. For a complete list of accommodation in the Algarve go to www.visitalgarve.pt.

The Conrad: Opened in September 2012 and the only Conrad hotel in Portugal, this luxurious residence, created in the form of a Moorish palace to reflect the Algarve's Moroccan influence, is already winning awards.

Voted the World's Leading New Resort at the World Travel Awards in December 2012, it's spa includes a Caribbean storm shower complete with piped-in birdsong and thunder and lightning effects.

Quinta do Lago, Almancil; +351 289 350 700; from ?209 (US$272) per night; www.conradalgarve.com

The Pine Cliffs Resort: Voted Portugal's Leading Family Resort in 2009 by World Travel Awards, the Pine Cliffs Resort includes a Sheraton Hotel and 280 apartments, town houses and villas.

Its restaurants serve seafood, Portuguese, Italian, Moroccan and Mediterranean cuisine.

There's also a 7,000-square-meter Kids Club and almost every leisure and sporting activity known to man.

Praia da Fal?sia, Albufeira; +351 289 500 100; from ?66 (US$86) per night; www.pinecliffs.com

Vila Gal? Ampalius Hotel: Located 10 meters from the marina in Vilamoura, the Vila Gal? Ampalius is a four-star beauty.

It has two outdoor swimming pools, great views from room balconies and is ideally situated to explore Vilamoura, the biggest resort town in Europe, loaded with nightclubs, restaurants and a casino.

Alameda Praia de Marina, Vilamoura; +351 289 303 900; from ?68 (US$88) per night; www.vilagale.co.uk

The Hotel Quinta do Lago: This beautiful hotel has a gracious staff. The rooms are good, food is great and views from the upper floor rooms across the Ria Formosa Nature Reserve, the Atlantic Ocean and coastline make for spectacular sunsets.

Quinta do Lago, Almancil; +351 289 350 350; from ?335 (US$435) per night; www.quintadolagohotel.com

Quinta Monte Serra: This charming farmhouse in the eastern Algarve, close to Tavira, is owned by?Jean-Jacques de Coninck. He's transformed four of the farm buildings into beautiful cottages, retaining the old rural exteriors while completely modernizing the interiors with kitchens and bathrooms.

The tranquillity is disturbed only by the occasional sounds of the local wildlife.

Esti Rainanteus, Tavira; +351 961 142 562; from ?350 (US$455) per week; www.monte-serra.com

For more details on all the Algarve go to www.visitalgarve.pt.

Source: http://travel.cnn.com/algarve-no-longer-just-retirement-519301

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Gene switch steers blood supply to the retina

Apr. 8, 2013 ? Normal functioning of the eye depends on a proper supply of blood to the retina. Light entering the eye passes through the cornea, the lens, and the vitreous body before reaching the retina, where it stimulates the nerves. If the retina contains too few or too many blood vessels -- i.e., if it is under- or oversupplied with blood -- a number of severe, often blinding eye diseases can develop.

An international group of researchers led by Professor Alfred Nordheim at the University of T?bingen's Interfaculty Institute for Cell Biology has found, using experiments on mice, that genes for blood vessel growth in the retina are "switched on" by a known factor -- a protein called SRF. The scientists showed that by eliminating this factor, they could artificially induce a certain disease profile in newborn mice and a different one in adult mice. Their results, which are published now in The Journal of Clinical Investigation, offer important clues on the diseases afflicting human eyes and provide starting-points for the development of treatments for defective retinae and vitreous bodies.

Professor Alfred Nordheim's team has been examining the serum response factor (SRF) and its various functions for several years. SRF regulates the function of many genes in the genome of mice and men -- thereby setting in motion distinct growth processes for organs. Experimenting on mice in the laboratory, the T?bingen researchers have developed sophisticated mechanisms to influence the activity of SRF and its co-factors in distinct types of cells and at defined time points when the organism reaches a certain developmental stage.

In the current study, the researchers switched off SRF in the blood vessels of mouse embryos, as well as in newborn and adult mice. As a result, the blood vessels in the retinae of the newborns were not fully developed. Their eye problems were very similar to certain hereditary forms of a disease affecting the retina and vitreous body in the human eye (vitreoretinopathy and Norrie disease). Children affected by it often go blind at an early age. In mice of adult ages, however, switching off SRF had the opposite effect -- too many new blood vessels were formed in the retina, oversupplying it with blood. Doctors have made corresponding observations in elderly patients with a certain form of age-related macular degeneration (AMD), a disease which increasingly damages the retina and leads to vision loss. It is characterized by dilated blood vessels and the formation of excess blood vessels.

"I expected that SRF would play a role in the development of the vessel system, because it generally works to ensure the formation of cellular protrusions and new branched cellular structures in many organs, for instance in the nervous system and the vascular system," says Alfred Nordheim. But, he added, it was astonishing how closely the pathology of mice with switched-off SRF resembled that of human patients with particular eye diseases. "I think we have established a very good model with which we can investigate these diseases much more precisely," Nordheim says. It represents an important step for research into possible treatments, he adds.

The study was carried out in collaboration with researchers at the Max Planck Institute for Molecular Biomedicine in M?nster (Prof. Adams), the Institute for Ophthalmic Research T?bingen (Prof. Seeliger), the Pathology Department at the T?bingen University Hospital (Prof. Wolburg) and the University of Texas, Dallas, USA (Prof. Olson).

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The above story is reprinted from materials provided by Universitaet T?bingen.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Christine Weinl, Heidemarie Riehle, Dongjeong Park, Christine Stritt, Susanne Beck, Gesine Huber, Hartwig Wolburg, Eric N. Olson, Mathias W. Seeliger, Ralf H. Adams, Alfred Nordheim. Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae. Journal of Clinical Investigation, 2013; DOI: 10.1172/JCI64201

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/3ht3UXX0QT8/130408133509.htm

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Tuesday, April 9, 2013

Atlanta food and drink events, April 8-14: Final Four specials, spring ...


Cook's Warehouse, Brookhaven Mon., April 8, 7 & 9 p.m. Simple Abundance Cooking Class: Southern Feast Celebrity Chef Art Smith's newest executive chef of Southern Art, Timothy Magee, will provide demonstrations and recipe instruction on southern staples, plus a wine tasting sponsored by Sherlock's Wine Merchant and a chance to win door prizes provided by Bella Cucina Artful Foods and Cabot Cheese. Details

Big Tex Decatur Mon., April 8, 6 p.m. March Madness Big Tex Decatur will screen the championship game, and is offering food and drink specials for fans. Details

BLT Steak Mon., April 8 Final Four Offer Guests who bring in any Final Four ticket stub will receive 10 percent off food and 20 percent off drinks. Details

Davio's Northern Italian Steakhouse Mon., April 8 Savory Spring Roll Bracket In conjunction with this year's NCAA's Final Four playoff tournament, Davio's will host its own final four showdown to decipher which of its signature spring rolls rules supreme. Details

Googie Burger Mon., April 8 Final Four Specials Googie Burger is offering special sliders to accompany a screening of the NCAA championship. Details

Nikolai's Roof Mon., April 8, 7 p.m. Final Four Specials The NCAA championship game will be playing on all four screens, and the restaurant is offering an $18 beer bucket special, as well. Details

Trader Vic's Mon., April 8 Final Four specials Trader Vic's celebrates the Final Four tournament with an $18 beer bucket special, along with other exciting events. Details

KR SteakBar Tue., April 9, 5 p.m. Food Bank Supper Club This edition of Food Bank Supper Club will be hosted by KR SteakBar, which will donate 20 percent of each diner's check to support hunger relief. Details

Miller Union Tue., April 9, 6-8:30 p.m. Miller Union Spring Harvest Dinner Miller Union chef Steven Satterfield will serve up a three-course family-style supper to celebrate the spring season. Details

Canoe Tue., April 9, 7 p.m. Wine Education Series Beverage Director Matt Bradford will host a four-course educational dinner with a guided wine tasting, focusing on 45th Parallel pinot noirs. Details

Atkins Park Wed., April 10, 9:30 p.m. Ping Pong Tournament Atkins Park and New Belgium Brewing Company will host a ping pong tournament to benefit the Atlanta Bicycle Coalition, and will offer prizes presented by New Belgium Brewing. Details

Atlanta Marriott Buckhead Thurs., April 11, 6 p.m. 9th Annual "A Taste of Buckhead Business" Expo The expo brings together premier restaurants and businesses to showcase the cultural diversity of the greater Buckhead community. Details

The Georgia Association of The American Institute of Architects Thurs., April 11, 6-9 p.m. Wine Reception and Silent Auction This is AIA|ATL's first temporary storefront gallery exhibition to showcase the talents of local and emerging designers. Details

Haven Thurs., April 11, 7 p.m. Haven Patio Party Chef Stephen Herman will be grilling and serving up seasonal bites paired with a selection of beer and wine. There will also be live music. Details

Rosebud Sat., April 13, 2-5 p.m. 2nd Annual Mother Clucker Fried Chicken Festival A gathering of Atlanta's top chefs will partake in a fried chicken cook-off in a tented lot next to Rosebud. Expect live music and other sweet treats. Details

Food 101 Sat., April 13, 2 p.m. Masters Tournament Viewing Party Join Food 101 to watch one of the final days of the Masters Tournament, with food and drink specials available all day. Details

The Terrapin Beer Company Sat., April 13, 4:30 p.m. Terrapin's Annual Anniversary Party This birthday party for Terrapin features casks, limited barrel-aged beers, the beer dunk tank, live music, and carnival games, and will benefit the Community Connection. Details

Crack in the Sidewalk Farmlet Sun., April 14, 3 p.m. Spring Tonic: A Benefit Dinner Celebrate spring while supporting local farmers at the Spring Tonic Benefit Dinner, hosted by chef Ryan Smith and mixologist Kellie Thorn of Empire State South. Details

Ponce City Market Sun., April 14, 6 p.m. New South Family Supper at Ponce City Market Celebrated chef-owners Anne Quatrano and Clifford Harrison announce the inaugural New South Family Supper, a benefit for the Southern Foodways Alliance, bringing together a cadre of the South's most innovative chefs. Details

Yeah! Burger Sun., April 14, 11 a.m. Meet the Farmer Learn where your food comes from on Yeah! Burger's greenspace. Details

Source: http://clatl.com/omnivore/archives/2013/04/08/atlanta-food-and-drink-events-april-8-14-final-four-specials-spring-harvest-dinners-and-more

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